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New Finding of Rise in H5N1 Virus (Avian Flu) Replikin Count

Replikins Global BioRadar Surveillance System™ Shows Replikin Count in H5N1 at Record High for 2010

BOSTON, Oct. 27, 2010 — BioRadar™ software correctly predicted the 2009 H1N1 (Swine Flu) outbreak a year in advance (, Replikins Press, 2008). The same rise in Replikin Count of these genomic Replikin genes, this time in the H5N1 (Bird Flu) virus, may similarly warn of the coming of severe outbreaks in H5N1.

Specifically, BioRadar™ analyzed two separate Replikins* genes, one for infectivity and one for lethality. The high H5N1 lethality gene Replikin Count, rising since 2006 (6.0+/-7.0), has continued to rise to a high in 2010 (9.1+/-8.5) (p<0.001). BioRadar™ predicted in 2009 an increase in H5N1 outbreaks and more outbreaks appeared in 16 countries by mid-2010. The previous low infectivity of H5N1, correlated with a low Replikin Count, has been reassuring. The finding in 2010 of a significant increase in the Replikin Count of the H5N1 infectivity gene as well, in "scout" viruses to 8.4, its highest level in 53 years, is of concern.

By means of BioRadar™ software, Replikins were identified in all sequences (N, H5N1=25,358) from PubMed and from Global BioRadar Surveillance System™ participants.

The studies were conducted by Samuel Bogoch, M.D., Ph.D. and Elenore S. Bogoch, M.D., Boston University School of Medicine and BioRadar UK, Ltd.

*About Replikins

Replikins are a new group of genomic peptide structures in viruses, other infectious disease agents, and cancer cells, which are associated with rapid replication ( Two genes have been isolated in silico in viruses and relate to infectivity and lethality respectively. The increase in Replikin concentration (Replikin Count=Number of Replikins per 100 amino acids) in the virus Infectivity Gene precedes an increase in clinical infectivity and spread; and an increase in the virus Lethality Gene precedes an increase in lethality clinically.

Contact: Dr. Sam Bogoch, 617-536-9711

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