eNewsroom for: Replikins

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Replikins Company Profile

Replikins, Ltd. develops and markets novel forecasting tools and synthetic vaccines to fight virulent rapidly replicating diseases including bird flu, malaria, and HIV. The company's predictive products and vaccines in development are based upon the company's discovery of Replikins, a new group of peptides related to the rapid replication function in viral and other diseases. The company has designed unique products to predict the emergence of virulent strains of particular diseases (FluForecastâ„¢) and is designing synthetic vaccines specifically tailored to combat a given strain and against shared properties of several strains (Syntopeâ„¢ vaccines). The company is partnering with governments and the private sector in providing predictive tools and vaccines in furtherance of the public health initiative to prevent and combat epidemics.

News from Replikins:

Highest Replikin Concentrations and Cyclical Behavior Related to Human Mortality Are Found in Malaria Trypanosomes

BOSTON, May 19, 2008 — Replikins Ltd. has found that very high concentrations of its replikin genetic sequences are found in the trypanosomes that are the infectious agents in malaria. The levels found by the company are in fact the highest replikin concentrations observed to date in any infectio…

Increases in West Nile Virus Replikin Concentrations Precede Increases in the Number of Human Cases

BOSTON, May 2, 2008 — Replikins Ltd. has found that the replikin concentration of West Nile Virus increased annually through two distinct cycles as the virus expanded in the U.S.: the first from 2000 to 2003, and the second from 2004 to 2007 (p less than 0.001). Increases in the annual number of human…

H1N1 Influenza Virus With Highest Replikin Count(TM) Since the 1918 Pandemic Identified in the U.S. and Austria

BOSTON, April 7, 2008 — Replikins Ltd. has found that the Replikin Count(TM) of the H1N1 strain of influenza virus has recently increased to 7.6 (plus/minus 1.4), its highest level since the 1918 H1N1 pandemic (p value less than 0.001). A rising Replikin Count of a particular influenza strain, ind…

Replikins Oral Vaccine Synthesized in 7 Days Protects 91% of Shrimp Against a Lethal Virus

BOSTON, March 11, 2008 — Replikins, Ltd. has announced development of a chemically synthesized vaccine specific to a Taura Syndrome virus structure based on its patented Replikins(TM) technology. When the vaccine was administered orally to shrimp, 91% survived a challenge by the lethal Taura…

FluForecast(R) Replikin Count(TM) Predicts That the H5N1 Cycle Which Began in 1996 Is Now Over

BOSTON, Feb. 11, 2008 — Replikins Ltd. announced that the quantitative analysis of Replikin Count(TM) in the virus gene structure predicts that the current H5N1 cycle is over. Sporadic outbreaks may continue, but the rapid epidemic spread and high mortality characteristics are expected to sub…

Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated

BOSTON, Dec. 11, 2007 — Replikins Ltd. today announced its latest findings regarding the virus replikin count in human H5N1 influenza virus. The company's software-driven analysis has found that the prevalence of these sequences has remained high in Indonesia; in addition, higher count…

AMAS Test Measures Lethal Replikin Gene Activity in Lung and Other Cancers

BOSTON, Dec. 6, 2007 — A gene related to rapid replication and lethality has been found to be present in, and to contain some identical protein sequences in, tobacco mosaic virus and non-small cell lung cancer. The early detection diagnostic test for cancer, the AMAS(R) test, appears to measure th…

Replikins LLC Finds West Nile Virus Replikin Count Has Reached Its Highest Recorded Value

BOSTON, AUG. 3, 2007 — Replikins LLC has discovered a new group of virus structural peptides within virus proteins, called replikins, which provide virus-specific advance quantitative warnings of rapid replication and the risk of epidemics. Replikins LLC has developed software called Repli…

Indonesia Reports Experiencing Human H5N1 Mortality Increase, as Predicted Last Year by Replikins' FluForecast(R) Quantitative Virus Analysis

BOSTON, June 8, 2007 — The results published in 2006 by Replikins, Ltd. showed that 2005-2006 FluForecast(R) virus data indicated clearly that 1) the mortality rate of human H5N1 was increasing markedly, and that 2) the first country in which this would be clinically realized would be Indonesia.…

FluForecast(R) Trial in 2006 Predicted High Human H5N1 Mortality in Indonesia

BOSTON, May 9, 2007 — When H5N1 was thought to be quiescent in 2006, in a prospective open trial, FluForecast(R), a software program which measures virus gene proteins, predicted high human mortality H5N1 outbreaks to come2. In addition, FluForecast technology predicted that the leading count…

Gene Segment Identified in Virulent Human H5N1 Viruses

Key discovery may enable development of vaccines, therapeutics BOSTON, Jan. 25, 2007 — Viruses whose genomes constantly mutate, such as the H5N1 "bird flu," are driving a race to find relatively unchanging segments of their genomes; successful identification of these segments may…

Human H5N1 Virus Replikin Count Overtakes That in H5N1 'Bird Flu'

BOSTON, Dec. 28, 2006 — A common question asked at current scientific conferences is: "Where did bird flu go?" The recent decrease in reported H5N1 human cases and bird outbreaks might indicate that the virus has become dormant. However, quantitative analysis by Replikins, Ltd. rele…

Rising H5N1 'Bird Flu' High-Virulence Sequences Found By Replikins, Ltd.

BOSTON, Nov. 6, 2006 — Replikins, Ltd. has completed a comprehensive quantitative analysis of H5N1 "bird flu" peptide sequences found in humans infected with H5N1 in the past nine years. The data, obtained from public sources, included 1,455 complete sequences from human specimens…

Advance Warning of H5N1 Influenza Outbreaks May Be Found in Shrimp Virus Reservoirs

BOSTON, Oct. 25, 2006 — Researchers at Replikins, Ltd.[1] have discovered that the shrimp viruses White Spot Syndrome virus (WSSV) and Taura Syndrome virus (TSV) – global lethal pathogens for shrimp – may be reservoirs for the peptide building blocks of H5N1, or bird flu virus. The H…

Replikins' FluForecast Software Pinpoints Change in Deadly Bird Flu Amino Acid Sequence in Humans

Single substitution discovered in current H5N1 was also found to be present in the last two major human pandemics of 1957 (H2N2) and 1968 (H3N2) BOSTON, June 2, 2006 — WHO and CDC spokespersons have recently announced that no significant worrisome sequence changes have been observed so far in H5N1…